Automated power gating methodology for dataflow-based reconfigurable systems

Modern embedded systems designers are required to implement efficient multi-functional applications, over portable platforms under strong energy and resources constraints. Automatic tools may help them in challenging such a complex scenario: to develop complex reconfigurable systems while reducing time-to-market. At the same time, automated methodologies can aid them to manage power consumption. Dataflow models of computation, thanks to their modularity, turned out to be extremely useful to these purposes. In this paper, we will demonstrate as they can be used to automatically achieve power management since the earliest stage of the design flow. In particular, we are focussing on the automation of power gating. The methodology has been evaluated on an image processing use case targeting an ASIC 90 nm CMOS technology

Mutual Impact between Clock Gating and High Level Synthesis in Reconfigurable Hardware Accelerators

With the diffusion of cyber-physical systems and internet of things, adaptivity and low power consumption became of primary importance in digital systems design. Reconfigurable heterogeneous platforms seem to be one of the most suitable choices to cope with such challenging context. However, their development and power optimization are not trivial, especially considering hardware acceleration components. On the one hand high level synthesis could simplify the design of such kind of systems, but on the other hand it can limit the positive effects of the adopted power saving techniques. In this work, the mutual impact of different high level synthesis tools and the application of the well known clock gating strategy in the development of reconfigurable accelerators is studied. The aim is to optimize a clock gating application according to the chosen high level synthesis engine and target technology (Application Specific Integrated Circuit (ASIC) or Field Programmable Gate Array (FPGA)). Different levels of application of clock gating are evaluated, including a novel multi level solution. Besides assessing the benefits and drawbacks of the clock gating application at different levels, hints for future design automation of low power reconfigurable accelerators through high level synthesis are also derived

Modelling and Automated Implementation of Optimal Power Saving Strategies in Coarse-Grained Reconfigurable Architectures

This paper focuses on how to efficiently reduce power consumption in coarse-grained reconfigurable designs, to allow their effective adoption in heterogeneous architectures supporting and accelerating complex and highly variable multifunctional applications. We propose a design flow for this kind of architectures that, besides their automatic customization, is also capable of determining their optimal power management support. Power and clock gating implementation costs are estimated in advance, before their physical implementation, on the basis of the functional, technological, and architectural parameters of the baseline design. Experimental results, on 90 and 45 nm CMOS technologies, demonstrate that the proposed approach guides the designer towards optimal implementation

Reconfigurable Adaptive Multiple Transform Hardware Solutions for Versatile Video Coding

Computer aided design is nowadays a must to quickly provide optimized circuits, to cope with stringent time to market constraints, and to be able to guarantee colliding constrained requirements. Design automation is exploited, whenever possible, to speed up the design process and relieve the developers from error prone customization, optimization and tuning phases. In this work we study the possibility of adopting automated algorithms for the optimization of reconfigurable multiple constant multiplication circuits. In particular, an exploration of novel reconfigurable Adaptive Multiple Transform circuital solutions adoptable in video coding applications has been conducted. These solutions have also been compared with the unique similar work at the state of the art, revealing to be beneficial under certain constraints. Moreover, the proposed approach has been generalized with some guidelines helpful to designers facing similar problems

Different Thymosin Beta 4 Immunoreactivity in Foetal and Adult Gastrointestinal Tract

Background: Thymosin beta 4 (T beta(4)) is a member of beta-thymosins, a family of peptides that play essential roles in many cellular functions. A recent study from our group suggested a role for T beta(4) in the development of human salivary glands. The aim of this study was to analyze the expression of T beta(4) in the human gut during development, and in the adult. Methodology/Principal Findings: Immunolocalization of T beta(4) was studied in autoptic samples of tongue, oesophagus, stomach, ileum, colon, liver and pancreas obtained from two human foetuses and two adults. T beta(4) appeared unevenly distributed, with marked differences between foetuses and adults. In the stomach, superficial epithelium was positive in foetuses and negative in adults. Ileal enterocytes were strongly positive in the adult and weakly positive in the foetuses. An increase in reactivity for T beta(4) was observed in superficial colon epithelium of adults as compared with the foetuses. Striking differences were found between foetal and adult liver: the former showed a very low reactivity for T beta(4) while in the adult we observed a strong reactivity in the vast majority of the hepatocytes. A peculiar pattern was found in the pancreas, with the strongest reactivity observed in foetal and adult islet cells. Significance: Our data show a strong expression of T beta(4) in the human gut and in endocrine pancreas during development. The observed differential expression of T beta(4) suggests specific roles of the peptide in the gut of foetuses and adults. The observed heterogeneity of T beta(4) expression in the foetal life, ranging from a very rare detection in liver cells up to a diffuse reactivity in endocrine pancreas, should be taken into account when the role of T beta(4) in the development of human embryo is assessed. Future studies are needed to shed light on the link between T beta(4) and organogenesis

Thymosin β 4 in colorectal cancer is localized predominantly at the invasion front in tumor cells undergoing epithelial mesenchymal transition.

Thymosin β 4 (Tβ(4)) is a ubiquitous peptide that plays pivotal roles in the cytoskeletal system and in cell differentiation during embryogenesis. Recently, a role for Tβ(4) has been proposed in experimental and human carcinogenesis. This study was aimed at evaluating the correlation between Tβ(4) immunoractivity and colorectal cancer, with particular attemption to tumor cells undergoing epithelial-mesenchymal transition.86 intestinal biopsies were retrospectively analyzed including 76 colorectal adenocarcinomas with evident features of epithelial-mesenchymal transition, and 10 samples of normal colorectal mucosa. Paraffin sections were immunostained for Tβ(4) and for E-cadherin. Total RNA was isolated from frozen specimens obtained, at surgery, from the normal colon mucosa, the deeper regions and the superficial tumor regions in four cases of colon cancer. Tβ(4) immunoreactivity was detected in the vast majority (59/76) of colon carcinomas, showing a patchy distribution, with well differentiated areas significantly more reactive than the less differentiated tumor zones. We also noted a zonal pattern in the majority of tumors, characterized by a progressive increase in immunostaining for Tβ(4) from the superficial toward the deepest tumor regions. The strongest expression for Tβ(4) was frequently detected in invading tumor cells with features of epithelial-mesenchymal transition. The increase in reactivity for Tβ(4) matched with a progressive decrease in E-cadherin expression in invading cancer cells. At mRNA level, the differences in Tβ(4) expression between the surrounding colon mucosa and the tumors samples were not significant.Our data show that Tβ(4) is expressed in the majority of colon cancers, with preferential immunoreactivity in deep tumor regions. The preferential expression of the peptide and the increase in intensity of the immunostaining at the invasion front suggests a possible link between the peptide and the process of epithelial mesenchymal transition, suggesting a role for Tβ(4) in colorectal cancer invasion and metastasis

Design and management of image processing pipelines within CPS : Acquired experience towards the end of the FitOptiVis ECSEL Project

Cyber-Physical Systems (CPSs) are dynamic and reactive systems interacting with processes, environment and, sometimes, humans. They are often distributed with sensors and actuators, characterized for being smart, adaptive, predictive and react in real-time. Indeed, image- and video-processing pipelines are a prime source for environmental information for systems allowing them to take better decisions according to what they see. Therefore, in FitOptiVis, we are developing novel methods and tools to integrate complex image- and video-processing pipelines. FitOptiVis aims to deliver a reference architecture for describing and optimizing quality and resource management for imaging and video pipelines in CPSs both at design- and run-time. The architecture is concretized in low-power, high-performance, smart components, and in methods and tools for combined design-time and run-time multi-objective optimization and adaptation within system and environment constraints.Peer reviewe

Coarse grain reconfiguration: Power estimation and management flow for hybrid gated systems

This work presents an automatic power estimation and implementation flow for coarse-grained reconfigurable systems, capable of guiding designers towards the optimal implementation of power-efficient systems. The entire flow is assessed over the reconfigurable computing core of a dedicated image processing accelerator, targeting an ASIC 45 nm technology